Molecular cloning of the genes encoding the muscarinic acetylcholine receptors has shwon that receptor subtypes classified on the basis of pharmacological properties are related polypeptides encoded by distinct genes. These studies have laso revealed the existence of novel muscarinic receptor subtypes. Functional analysis of each of the subtypes expressed in mammalian cells indicates that the different subtypes activate distinct biochemical pathways, a finding that explains the tissue‐specific physiological response elicited by the neurotransmitter, acetylcholine.

In this paper we provide evidence from Japan that bears on a general theory of agenda power in legislatures. By agenda power we mean the power to determine: (a) which bills are considered in the plenary session of the legislature and (b) restrictions on debate and amendment to these bills, when they are considered. While a substantial amount of work has focused on the second category of agenda power, including studies of special rules in the US House (e.g., Sinclair forthcoming), (...) closure in the UK House of Commons (e.g., Cox, 1987; Dion, 1997), and the guillotine in the French National Assembly (e.g., Huber, 1996), there is very little on the first and arguably more fundamental sort of agenda power. This agenda power is our focus here, and henceforth when we refer to we shall mean this narrower conception. (shrink)

ABSTRACT Global biodiversity declines are increasingly recognized as profound ecological and social crises. In areas subject to colonialization, these declines have advanced in lockstep with settler colonialism and imposition of centralized resource management by settler states. Many have suggested that resurgent Indigenous-led governance systems could help arrest these trends while advancing effective and socially just approaches to environmental interactions that benefit people and places alike. However, how dominant management and conservation approaches might be decolonized (i.e., how their underlying colonial structure (...) might be addressed, transformed, and replaced) is not always clear. Here, we describe a ‘Decolonial Model of Environmental Management and Conservation’ as an alternative paradigm to dominant approaches of conservation and management. The tenets of the model describe characteristics that might be expected of decolonized management, contrasted with those of dominant state-led approaches such as those embedded in the North American Model of Wildlife Conservation. The model does not prescribe how Indigenous governments or communities ought to govern their own territories, but instead offers insights into how external management and conservation agencies and practitioners might support (or stop impeding) Indigenous-led governance. We illustrate the model with a conservation ‘bright spot’: grizzly bear stewardship in the area now referred to as the Great Bear Rainforest in British Columbia, Canada, with a focus on work led by or in collaboration with, and within the territories of, the Haíɫzaqv, Kitasoo/xai’xais, Nuxalk, and Wuikinuxv First Nations. While acknowledging the important context-specific variability among place-based management and conservation applications, we also discuss the model’s broader applicability. (shrink)

The play contains two different fates of Wallenstein—the first, the fate of the determinate progress of a decision, the second, the fate of this decision and the forces opposing it. Each can be taken as a tragic whole in itself. The first: Wallenstein, a great man—for as his own man, as an individual, he has held command [geboten] over many men—appears as this being in command [gebietende], with the splendor and enjoyment of this reign, mysterious because he holds no mystery. (...) The determinate divides itself, of necessity, against his indeterminateness, into two branches, the first internal, the second external. The internal is not a struggle for determination but a fermenting of it; he has personal stature, fame as a commander, as the deliverer of an empire through individuality, command over many who obey him, the fear of friend and foe; he is himself above [erhaben] determination as subject to the emperor and state he has delivered, still less to fanaticism; his plans themselves must be still higher [erhaben]; what determination can satisfy him? He prepares for himself the means for the greatest [end] of his time, to confer [gebieten], in general, peace upon Germany, and, in particular, to acquire for himself a kingdom, and for his friends—comparable rewards.—[But] his higher [erhabene], self-sufficient soul plays [spielende] with the greatest end, and, for this reason, it is without character and can grasp no end, it searches for something higher to prod it. The independent man, who is yet alive and no monk, wants to shift the guilt of determination from himself, and, if there is nothing that can command [gebieten] him—there can be no such thing—then he creates for himself what will command [gebiete] him. Wallenstein seeks his decision, his action and his fate, in the stars. Precisely the one-sidedness of indeterminate being in the midst of nothing but determinateness, independence within nothing but dependences, brings him into relation with a thousand determinations; his friends built these up into ends that become his, his enemies too, against which they must however fight; and this determination, which has developed itself in the fermenting matter—for these are human beings—binds him and renders him dependent, it is not something he created, rather it seizes him. This succumbing of the indeterminate before the determinate is a highly tragic being, it is posited as great and of consequence.—In this, reflection will not justify genius, only present it. The impression of this as a tragic whole stands out for me very vividly. If this whole were a novel, then one could demand to see the determination clarified,—namely, that which Wallenstein has brought to this rule over the people. They are fettered by greatness, lack of determination, his boldness for their sake. It is however part of the play, yet cannot be acted out dramatically, i.e., appear as determining and at the same time determinate. It appears only as a shadow-play [Schattenbild], as it is called in the Prologue, perhaps in a different sense; but the camp is this rule, as something that came into being [gewordenes], a product. (shrink)

Background: Mental healthcare needs person-tailored interventions. Experience Sampling Method (ESM) can provide daily life monitoring of personal experiences. This study aims to operationalize and test a measure of momentary reward-related Quality of Life (rQoL). Intuitively, quality of life improves by spending more time on rewarding experiences. ESM clinical interventions can use this information to coach patients to find a realistic, optimal balance of positive experiences (maximize reward) in daily life. rQoL combines the frequency of engaging in a relevant context (a (...) ‘behavior setting’) with concurrent (positive) affect. High rQoL occurs when the most frequent behavior settings are combined with positive affect or infrequent behavior settings co-occur with low positive affect. Methods: Resampling procedures (Monte Carlo experiments) were applied to assess the reliability of rQoL using various behavior setting definitions under different sampling circumstances, for real or virtual subjects with low-, average- and high contextual variability. Furthermore, resampling was used to assess whether rQoL is a distinct concept from positive affect. Virtual ESM beep datasets were extracted from 1058 valid ESM observations for virtual and real subjects. Results: Behavior settings defined by Who-What contextual information were most informative. Simulations of at least 100 ESM observations are needed for reliable assessment. Virtual ESM beep datasets of a real subject can be defined by Who-What-Where behavior setting combinations. Large sample sizes are necessary for reliable rQoL assessments, except for subjects with low contextual variability. rQoL is distinct from positive affect. Conclusion: rQoL is a feasible concept. Monte Carlo experiments should be used to assess the reliable implementation of an ESM statistic. Future research in ESM should asses the behavior of summary statistics under different sampling situations. This exploration is especially relevant in clinical implementation, where often only small datasets are available. (shrink)